課程資訊
課程名稱
 結構生物學概論
Introduction to Structural Biology 
開課學期
 106-1 
授課對象
 生命科學院  生化科技研究所  
授課教師
 楊啟伸 
課號
 BST5008 
課程識別碼
 B22 U0180 
班次
  
學分
 2.0 
全/半年
 半年 
必/選修
 必修 
上課時間
 星期四6,7(13:20~15:10) 
上課地點
 農化二B10 
備註
 碩士班A群組必修10學分課程之一。
總人數上限：80人 
Ceiba 課程網頁
 http://ceiba.ntu.edu.tw/1061BST5008_ 
課程簡介影片
 
核心能力關聯
 本課程尚未建立核心能力關連
課程大綱
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課程概述

This is a class integrates the concepts of structural biology and bioinformatics. The basic principle of amino acids and structre will be explained first, then the modern methods to resolve atomic resolution of protein structures. The relation of protein structure and function will be emphasized in the third part of this class. Bioinformatic principles, methods and modern developments will be followed. 

課程目標
 1. Understand amino acids and protein structures.
2. Modern approaches to resolve protein structure.
3. Protein structure and function.
4. Software-based analysis of protein sequence.
5. Bioinformatic theories
6. Current developments of bioinformatics methods. 
課程要求
 This class will be taught in English. 
預期每週課後學習時數
  
Office Hours
  
指定閱讀
 待補 
參考書目
 1. David Whitford (2005). Proteins : Structure and Function. John Wiley & Sons, Hoboken, NJ. USA.
2. Gregory A. Petsko and Dagmar Ringe (2003). Protein Structure and Function, 4th ed., New Science Press, Waltham, MA.
3. Materials are updated when new developments occur. 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 Mid-term 
30% 
  
2. 
 Final exam 
50% 
 Bioinformatic part could composed of presentation, too. 
3. 
 Presentation 
20% 
  
 
課程進度
週次
日期
單元主題
第1週
 9/14  <mark>1. Concepts of structural biology
2. What will be taught in this class</mark> 
第2週
 9/21  <mark>Amino acids and structure (1/2)</mark> 
第3週
 9/28  <mark>Amino acids (2/2)</mark> 
第4週
 10/05  <mark>Five different basic structural elements: Alpha helix, Beta sheet, Beta turn, Beta bulge and Loop

Five protein structural arrangements </mark> 
第5週
 10/12  <mark>1. Protein Functions in cells
2. Motif
3. Protein Conformational Changes</mark> 
第6週
 10/19  <mark>Software Tools
Resolving protein structures (I):
1) Whole picture of current methods
2) CryoEM and NMR</mark> 
第7週
 10/26  <mark>Resolving protein structures (II):
1) X-ray diffraction (1/2): Crystal growing and Diffraction</mark> 
第8週
 11/02  <mark>Resolving protein structures (III):
X-ray diffraction (2/2)
CryoEM</mark> 
第9週
 1/09  <mark>Midterm Exam</mark> 
第10週
 11/16  <mark>*** Form Groups for Presentation ***
Resolving protein structures (IV):
X-ray diffraction: A Review
All about PDB file</mark>
寄名單給<mark><i><b>陳容碩</mark></i></b> R06B22030@ntu.edu.tw> 
第11週
 11/23  <mark>BYOC (Bring your own computer) day:
1. Sequence analysis
2. Software usage.</mark> 
第12週
 11/30  <mark>Structural Biology and Bioinformatics: Structural prediction by pen and paper</mark> 
第13週
 12/07  <mark>Structural Biology and Life Science:
1. Swiss Model and SOSUI
2. Photoreceptor: protein with chromophore</mark> 
第14週
 12/14  <mark>分組報告：1a, 1b, 2a and 2b 組 </mark> 
第15週
 12/21  <mark>Structural Biology and Life Science:
3. Membrane protein science
分組報告 3a 和 3b 組</mark> 
第16週
 12/28  <mark>Structural Biology and Life Science:
4. Signal transduction through G-protein
分組報告 4a 和 4b 組</mark> 
第17週
 1/04  <mark>Structural Biology and Life Science:
5. Signal transduction in two-component system
分組報告 5a 和 5b 組</mark>